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Optimization of Throughput Conditions for Scale-up of a Roller Compacted Product – 2009

Released By Thermo Fisher Scientific Pharma Services

The purpose of this study was to establish the design space and operational conditions for the roller compaction process of a placebo formulation that closely represents a low-dose active formulation. The ribbon density, tensile strength, mean granule size and granule surface area can impact the process.

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